Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth.
J Agric Food Chem
; 63(44): 9715-21, 2015 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-26499209
ABSTRACT
The functional components in soymilk may vary depending upon the fermentation process. A fermented soymilk product (FSP) obtained by incubation with the microorganisms of intestinal microflora was found to reduce the risk of breast cancer. Guided by the inhibitory activities against breast cancer cells, two cytotoxic compounds, daidzein and (S)-latifolicinin A, were isolated from the FSP by repetitive extraction and chromatography. Latifolicinin A is the n-butyl ester of ß-(4-hydroxyphenyl)lactic acid (HPLA). A series of the ester and amide derivatives of (S)-HPLA and L-tyrosine were synthesized for evaluation of their cytotoxic activities. In comparison, (S)-HPLA derivatives exhibited equal or superior inhibitory activities to their L-tyrosine counterparts, and (S)-HPLA amides showed better cytotoxic activities than their corresponding esters. In particular, (S)-HPLA farnesyl amide was active to triple-negative MDA-MB-231 breast cancer cells (IC50 = 27 µM) and 10-fold less toxic to Detroit-551 normal cells.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glycine max
/
Neoplasias de la Mama
/
Extractos Vegetales
/
Leche de Soja
/
Proliferación Celular
/
Amidas
/
Lactatos
Idioma:
En
Revista:
J Agric Food Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
Taiwán