Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh.
Am J Clin Nutr
; 103(1): 236-49, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26607935
ABSTRACT
BACKGROUND:
Maternal undernutrition and newborn stunting [birth length-for-age z score (LAZ) <-2] are common in Bangladesh.OBJECTIVE:
The objective was to evaluate the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PLs) on birth outcomes.DESIGN:
We conducted a cluster-randomized effectiveness trial (the Rang-Din Nutrition Study) within a community health program in rural Bangladesh. We enrolled 4011 pregnant women at ≤20 gestational weeks; 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 µg folic acid) and 16 clusters received LNS-PLs (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals. Both of the supplements were intended for daily consumption until delivery. Primary outcomes were birth weight and length.RESULTS:
Infants in the LNS-PL group had higher birth weights (2629 ± 408 compared with 2588 ± 413 g; P = 0.007), weight-for-age z scores (-1.48 ± 1.01 compared with -1.59 ± 1.02; P = 0.006), head-circumference-for-age z scores (HCZs; -1.26 ± 1.08 compared with -1.34 ± 1.12; P = 0.028), and body mass index z scores (-1.57 ± 1.05 compared with -1.66 ± 1.03; P = 0.005) than those in the IFA group; in adjusted models, the differences in length (47.6 ± 0.07 compared with 47.4 ± 0.04 cm; P = 0.043) and LAZ (-1.15 ± 0.04 compared with -1.24 ± 0.02; P = 0.035) were also significant. LNS-PLs reduced the risk of newborn stunting (18.7% compared with 22.6%; RR 0.83; 95% CI 0.71, 0.97) and small head size (HCZ <-2) (20.7% compared with 24.9%; RR 0.85; 95% CI 0.73, 0.98). The effects of LNS-PL on newborn stunting were greatest in infants born before a 10-wk interruption in LNS-PL distribution (n = 1301; 15.7% compared with 23.6%; adjusted RR 0.69; 95% CI 0.53, 0.89) and in infants born to women ≤24 y of age or with household food insecurity.CONCLUSION:
Prenatal lipid-based nutrient supplements can improve birth outcomes in Bangladeshi women, especially those at higher risk of fetal growth restriction. This trial was registered at clinicaltrials.gov as NCT01715038.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Trofoterapia
Asunto principal:
Peso al Nacer
/
Estatura
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Grasas de la Dieta
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Suplementos Dietéticos
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Desarrollo Fetal
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Retardo del Crecimiento Fetal
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Trastornos del Crecimiento
Tipo de estudio:
Clinical_trials
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Etiology_studies
/
Prognostic_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2016
Tipo del documento:
Article