Sesquiterpenoids and further diterpenoids from the rare Chloranthaceae plant Chloranthus sessilifolius.
J Asian Nat Prod Res
; 17(12): 1220-30, 2015.
Article
en En
| MEDLINE
| ID: mdl-26652052
ABSTRACT
Two new dimeric lindenane-type sesquiterpenoids (1 and 2, named chlorasessilifols A and B, resp.), one new ent-podocarpane-type C17 norditerpenoid (3), and one new ent-torarane-type diterpenoid (4), along with seven known terpenoids, were isolated from the whole plant of Chloranthus sessilifolius. The new structures were established by means of spectroscopic methods and/or observed cotton effects in the circular dichroism spectra. Among the isolates, 3α,7ß-dihydroxy-ent-abieta-8,11,13-triene (11) exhibited significant anti-neuroinflammatory activity by inhibiting the nitric oxide production in lipopolysaccharide-stimulated murine BV-2 microglial cells, with an IC50 value of 4.3 µM.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Sesquiterpenos
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Medicamentos Herbarios Chinos
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Antiinflamatorios no Esteroideos
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Magnoliopsida
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Diterpenos
Idioma:
En
Revista:
J Asian Nat Prod Res
Año:
2015
Tipo del documento:
Article
País de afiliación:
China