Cytotoxic Cytochalasins and Other Metabolites from Xylariaceae sp. FL0390, a Fungal Endophyte of Spanish Moss.
Nat Prod Commun
; 10(10): 1655-8, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26669096
ABSTRACT
Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50S of 0.2-5.0 µM.
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Bases de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Citocalasinas
/
Tillandsia
/
Endófitos
/
Antineoplásicos
Idioma:
En
Revista:
Nat Prod Commun
Año:
2015
Tipo del documento:
Article