Improving Motor Corticothalamic Communication After Stroke Using Real-Time fMRI Connectivity-Based Neurofeedback.
Neurorehabil Neural Repair
; 30(7): 671-5, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-26671217
ABSTRACT
BACKGROUND:
Two thirds of stroke survivors experience motor impairment resulting in long-term disability. The anatomical substrate is often the disruption of cortico-subcortical pathways. It has been proposed that reestablishment of cortico-subcortical communication relates to functional recovery.OBJECTIVE:
In this study, we applied a novel training protocol to augment ipsilesional cortico-subcortical connectivity after stroke. Chronic stroke patients with severe motor impairment were provided online feedback of blood-oxygenation level dependent signal connectivity between cortical and subcortical regions critical for motor function using real-time functional magnetic resonance imaging neurofeedback.RESULTS:
In this proof of principle study, 3 out of 4 patients learned to voluntarily modulate cortico-subcortical connectivity as intended.CONCLUSIONS:
Our results document for the first time the feasibility and safety for patients with chronic stroke and severe motor impairment to self-regulate and augment ipsilesional cortico-subcortical connectivity through neurofeedback using real-time functional magnetic resonance imaging.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
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Imagen por Resonancia Magnética
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Accidente Cerebrovascular
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Neurorretroalimentación
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Rehabilitación de Accidente Cerebrovascular
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Vías Nerviosas
Idioma:
En
Revista:
Neurorehabil Neural Repair
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos