Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress.
Oxid Med Cell Longev
; 2016: 9573291, 2016.
Article
en En
| MEDLINE
| ID: mdl-26881048
ABSTRACT
This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria. In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria. The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS. We further confirmed in vitro, and what is more, we found that APS may ameliorate mitochondrial dysfunction through Sirt1 pathway. Based on the results, we may figure out part of the molecular mechanism of mitochondrial amelioration by APS.
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Bases de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Estrés Oxidativo
/
Planta del Astrágalo
/
Dinámicas Mitocondriales
Idioma:
En
Revista:
Oxid Med Cell Longev
Año:
2016
Tipo del documento:
Article