New Cytotoxic Tigliane Diterpenoids from Croton caudatus.
Planta Med
; 82(8): 729-33, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-27002392
ABSTRACT
Three new tigliane-type diterpenoids were isolated from the methanolic extract of the twigs and leaves of Croton caudatus, trivially named crotusins A-C (1-3). The structures of compounds 1-3 were elucidated on the basis of extensive spectral methods. These new compounds were highly oxygenated and heavily substituted. Cytotoxic activity against five human tumor cell lines was assessed for compounds 1-3 of which compound 3 showed significant inhibitory activity with IC50 values ranging from 0.49 to 4.19 µM against these cells, while crotusins A and B exhibited moderate activity.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Medicamentos Herbarios Chinos
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Croton
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Diterpenos
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Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Planta Med
Año:
2016
Tipo del documento:
Article