Vitamin D and vitamin B12 deficiencies are common in patients with midgut carcinoid (SI-NET).
Eur J Clin Nutr
; 70(9): 990-4, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27026421
ABSTRACT
BACKGROUND/OBJECTIVES:
Patients with small intestinal neuroendocrine tumours (SI-NET) often have diarrhoea from hormonal overproduction, surgery and medical treatment, leading to malabsorption of bile salts, fats, vitamin B12 and fat-souble vitamins. This could lead to malnutrition. SUBJECTS/METHODS:
We assessed nutritional status in 50 consecutive out patients with disseminated SI-NET, 25 patients in each cohort. The first cohort was descriptive and the second cohort supplemented with vitamin D, B12 and calcium. Vitamin D deficiency was defined as <50 nmol/l. All patients were assessed by clinical chemistry and dual-energy X-ray absorptiometry (DXA) and interviewed about weight changes, appetite, gastrointestinal disorders, sunhabits and the use of supplements.RESULTS:
In the first cohort, 29% of the patients were severely and 17% moderately vitamin D deficient. In patients without prior substitution, 32% had subnormal vitamin B12 levels. Seventy-six percent had low bone density. In the second cohort with vitamin and mineral supplementation, none had severe vitamin D deficiency, but 28% had moderate deficiency. No patient had subnormal vitamin B12 levels. Sixty percent had low bone density. The serum levels of vitamin D and B12 were higher and parathyroid hormone (PTH) lower in the second cohort compared with the first cohort (P⩽0,022). Vitamin D and PTH were negatively correlated, r=-30, P=⩽0.036.CONCLUSIONS:
Low serum levels of vitamin D and vitamin B12, and low bone density are common in patients with disseminated SI-NET. Supplementation of vitamin D, B12 and calcium resulted in higher serum levels of vitamins, lower PTH levels and diminished severe vitamin D deficiency and is thus recommended as standard care.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina D
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Deficiencia de Vitamina B 12
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Tumor Carcinoide
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Densidad Ósea
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Absorción Intestinal
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Neoplasias Intestinales
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Intestino Delgado
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Eur J Clin Nutr
Año:
2016
Tipo del documento:
Article
País de afiliación:
Suecia