[DIURETIC ACTIVITY OF 4-O-CARBOXYPHENYL-D-GLUCOPYRANOSIDE SODIUM SALT ADMINISTERED VIA DIFFERENT ROUTES].
Eksp Klin Farmakol
; 79(1): 20-2, 2016.
Article
en Ru
| MEDLINE
| ID: mdl-27159953
ABSTRACT
It was compared the diuretic activity of the sodium salt of 4-(O-ß-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 µmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(O-ß-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(O-ß-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
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Bases de datos:
MEDLINE
Asunto principal:
Benzoatos
/
Diuréticos
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Año:
2016
Tipo del documento:
Article