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[Cellular delivery of modified peptide nucleic acids: a review].
Sheng Wu Gong Cheng Xue Bao ; 32(3): 292-305, 2016 Mar.
Article en Zh | MEDLINE | ID: mdl-27349112
ABSTRACT
Peptide nucleic acid (PNA) is a DNA surrogate in which the phosphate deoxyribose backbone of DNA is replaced by repeating N-(2-aminoethyl)glycine units. PNA can hybridize to the complementary DNA and RNA with higher affinity than their oligonucleotide counterparts. This character of PNA not only makes it a new tool for the studies of molecular biology but also the potential candidate for gene-targeting drugs. The non-ionic backbone of PNA leads to stable hybrids with the nucleic acids, but at the same time, the neutral backbone results in poor cellular uptake. To address this problem, studies on modified PNA progress rapidly in recent years. We reviewed literature reports combined with our study about the delivery methods, including backbone modified PNA and PNA-ligand conjugates, and the cellular uptake of modified PNA. In addition, we summarized the problems and future prospect of the cellular delivery of modified PNA.
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Bases de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Ácidos Nucleicos de Péptidos Idioma: Zh Revista: Sheng Wu Gong Cheng Xue Bao Año: 2016 Tipo del documento: Article
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Bases de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Ácidos Nucleicos de Péptidos Idioma: Zh Revista: Sheng Wu Gong Cheng Xue Bao Año: 2016 Tipo del documento: Article