Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice.
J La State Med Soc
; 168(3): 101-3, 2016.
Article
en En
| MEDLINE
| ID: mdl-27389379
ABSTRACT
Intralipid emulsion therapy is well-established for the treatment of local-anesthetic systemic toxicities. In recent years, its role has expanded as an important therapeutic agent in the reversal of other types of drug overdoses, including certain types of antipsychotics, antidepressants, antiarrhythmics, and calcium channel blockers. A literature review identified thirty-one case reports including forty-nine separate drug overdose cases involving ten separate drug classes which were successfully reversed with Intralipid. The present clinical case study describes an elderly unresponsive woman refractory to conventional treatments after ingesting a potentially lethal amount of 5.6 grams of diltiazem in a suicide attempt. After treatment with Intralipid over a twenty-four hour period, the patient's hemodynamic and metabolic derangements were corrected and stabilized completely. Intralipid emulsion rescue therapy provides another potential strategy for the reversal of many drug toxicities, most likely by providing a lipid layer safety net for drug overdose by passive diffusion. Clinicians are urged to embrace an expanded role of Intralipid emulsion rescue therapy, not only for local anesthetic drug toxicities, but also for other lipophilic drug overdoses.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Fosfolípidos
/
Aceite de Soja
/
Diltiazem
/
Emulsiones Grasas Intravenosas
/
Sobredosis de Droga
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J La State Med Soc
Año:
2016
Tipo del documento:
Article