α-Chymotrypsin regulates free fatty acids and UCHL-1 to ameliorate N-methyl nitrosourea induced mammary gland carcinoma in albino wistar rats.
Inflammopharmacology
; 24(5): 277-286, 2016 Oct.
Article
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| MEDLINE
| ID: mdl-27671329
ABSTRACT
This study was undertaken to investigate the effect of α-chymotrypsin on methyl nitrosourea (MNU) induced mammary gland carcinoma in albino wistar rats. Animals were randomized into four groups (six animals in each). Group I (sham control 0.9 % normal saline p.o.); Group II (toxic control, MNU 47 mg/kg, i.v.); Group III (α-chymotrypsin, 5 mg/kg, p.o.); Group IV (α-chymotrypsin, 10 mg/kg p.o.). Toxicity was induced by single i.v. injection of MNU followed by α-chymotrypsin supplementation therapy for 100 days. MNU treatment was evident with increased alveolar bud count, differentiation score, upregulated inflammatory enzymes markers (COX, LOX and NO) antioxidative stress markers (TBARs, SOD, catalase and GSH).MNU associated toxicity was also ascertained by PGP 9.5 and NF-κB expression in the mammary gland tissue followed by FAME analysis for fatty acid profiling. α-chymotrypsin afforded significant protection against the deleterious effects of MNU.
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Bases de datos:
MEDLINE
Asunto principal:
Quimotripsina
/
Ubiquitina Tiolesterasa
/
Ácidos Grasos no Esterificados
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Neoplasias Mamarias Experimentales
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Metilnitrosourea
Idioma:
En
Revista:
Inflammopharmacology
Año:
2016
Tipo del documento:
Article
País de afiliación:
India