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The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice.
Geng, Yan; Sun, Qing; Li, Wang; Lu, Zhen-Ming; Xu, Hong-Yu; Shi, Jin-Song; Xu, Zheng-Hong.
Afiliación
  • Geng Y; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Sun Q; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Li W; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Lu ZM; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Xu HY; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Shi JS; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
  • Xu ZH; School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China.
Mol Nutr Food Res ; 61(4)2017 04.
Article en En | MEDLINE | ID: mdl-27983763
SCOPE: Myricetin is found in most berries, vegetables, and various medicinal herbs, which has been reported to possess various bio-activities. However, the role of myricetin on liver fibrosis remains to be elucidated. METHODS AND RESULTS: Hepatic stellate cell (HSC) line CFSC-8B was stimulated by transforming growth factor ß1 (TGF-ß1) or platelet-derived growth factor BB (PDGF-BB) to induce liver fibrosis in vitro. The results showed that myricetin significantly ameliorated TGF-ß1- or PDGF-BB-induced HSCs activation, cell migration, and extracellular matrix production; blocked TGF-ß1-induced phosphorylation of Smad2, P38, extracellular signal-regulated kinase (ERK), and protein kinase B (Akt); and downregulated PDGF-BB stimulated phosphorylation of extracellular signal-regulated kinase and Akt in HSCs in a dose-dependent manner. Meanwhile, the carbon tetrachloride (CCl4 ) induced mouse model has been used to study antifibrosis role of myricetin in vivo. Our data demonstrated that myricetin suppressed α-smooth muscle actin and collagen type I deposition and blocked phosphorylation of Smad2, mitogen-activated protein kinases, and Akt in CCl4 -treated mice. CONCLUSION: Myricetin inhibits the activation of HSCs and ameliorates CCl4 -induced liver fibrosis in mice and may serve as a potential therapeutic agent in the treatment of liver fibrosis.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Flavonoides / Factor de Crecimiento Derivado de Plaquetas / Tetracloruro de Carbono / Factor de Crecimiento Transformador beta1 Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Nutr Food Res Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Flavonoides / Factor de Crecimiento Derivado de Plaquetas / Tetracloruro de Carbono / Factor de Crecimiento Transformador beta1 Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Nutr Food Res Año: 2017 Tipo del documento: Article País de afiliación: China