Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes.

Ye, Hanfeng; Ha, Mei; Yang, Min; Yue, Ping; Xie, Zhengyuan; Liu, Changjiang

Ye, Hanfeng; Ha, Mei; Yang, Min; Yue, Ping; Xie, Zhengyuan; Liu, Changjiang.

Afiliación

Ye H; Yunnan Key Lab of Fertility Regulation and Minority Birth Health, Yunnan Population and Family Planning Science and Technology Research Institute, Yunnan 650021, P.R. China.
Ha M; School of Nursing, Chongqing Medical and Pharmaceutical College, Chongqing 400020, P.R. China.
Yang M; Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China.
Yue P; Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China.
Xie Z; Yunnan Key Lab of Fertility Regulation and Minority Birth Health, Yunnan Population and Family Planning Science and Technology Research Institute, Yunnan 650021, P.R. China.
Liu C; Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China.

Sci Rep ; 7: 40153, 2017 01 09.

Article en En | MEDLINE | ID: mdl-28065941

Asunto(s)

Dietilhexil Ftalato/toxicidad; Disruptores Endocrinos/toxicidad; Homeostasis/efectos de los fármacos; Hígado/efectos de los fármacos; Transducción de Señal; Hormonas Tiroideas/metabolismo; Animales; Células Cultivadas; Genes ras; Humanos; Hipotálamo/efectos de los fármacos; Hipotálamo/metabolismo; Hígado/enzimología; Hígado/patología; Sistema de Señalización de MAP Quinasas; Masculino; Estrés Oxidativo; Fosfatidilinositol 3-Quinasa/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo; Receptores de Hormona Liberadora de Tirotropina/metabolismo; Células Epiteliales Tiroideas/efectos de los fármacos; Glándula Tiroides/patología; Glándula Tiroides/ultraestructura

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hormonas Tiroideas / Transducción de Señal / Dietilhexil Ftalato / Disruptores Endocrinos / Homeostasis / Hígado Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article

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