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Combining nanoscale magnetic nimodipine liposomes with magnetic resonance image for Parkinson's disease targeting therapy.
Ji, Bingshuo; Wang, Meili; Gao, Dawei; Xing, Shanshan; Li, Lei; Liu, Lanxiang; Zhao, Min; Qi, Ximing; Dai, Kun.
Afiliación
  • Ji B; Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Wang M; Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Gao D; Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Xing S; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Li L; Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Liu L; Applying Chemistry Key Lab of Hebei Province, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, PR China.
  • Zhao M; Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
  • Qi X; Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
  • Dai K; Department of Pathology, the First Hospital of Qinhuangdao, No. 258 Cultural Street, Qinhuangdao 066000, PR China.
Nanomedicine (Lond) ; 12(3): 237-253, 2017 Feb.
Article en En | MEDLINE | ID: mdl-28093036
ABSTRACT

AIM:

To enhance drug targeting and blood-brain barrier penetration for Parkinson's disease (PD), a novel nanoscale magnetic nimodipine (NMD) delivery system was designed and prepared. MATERIALS &

METHODS:

The PD rats were established and treated with free NMD or Fe3O4-modified NMD liposomes (Fe3O4-NMD-lips). Then, factional anisotropy values were measured by MRI to evaluate therapy efficacy.

RESULTS:

Fe3O4-NMD-lips showed the best neuroprotective effect, and the NMD concentration of lesions was 2.5-fold higher in Fe3O4-NMD-lips group than that of free NMD group.

CONCLUSION:

These results demonstrated that the magnetic drug system had a great potential to cross the blood-brain barrier and provided a noninvasive and effective therapeutic strategy for PD.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Enfermedad de Parkinson / Nimodipina / Fármacos Neuroprotectores / Nanopartículas de Magnetita / Liposomas Idioma: En Revista: Nanomedicine (Lond) Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Enfermedad de Parkinson / Nimodipina / Fármacos Neuroprotectores / Nanopartículas de Magnetita / Liposomas Idioma: En Revista: Nanomedicine (Lond) Año: 2017 Tipo del documento: Article