Validation of Recipes for Double-Blind Placebo-Controlled Challenges With Milk, Egg White, and Hazelnut.
J Investig Allergol Clin Immunol
; 27(1): 40-45, 2017.
Article
en En
| MEDLINE
| ID: mdl-28211344
ABSTRACT
BACKGROUND:
The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC.METHODS:
We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated. In each phase, participants tried 3 samples (2 active-1 placebo or 2 placebo-1 active) and had to identify the odd one. In phase 1, the 3 samples were given simultaneously, whereas in phase 2, the 3 samples of foods that failed validation in phase 1 were given sequentially. A visual analog scale (VAS) ranging from 1 to 10 was used to evaluate how much participants liked the recipes.RESULTS:
In phase 1, the egg white recipe was validated (n=89 volunteers, 38.9% found the odd sample, P=.16). Milk and hazelnut recipes were validated in phase 2 (for both foods, n=30 participants, 36.7% found the odd sample, P=.36). Median VAS scores for the 3 recipes ranged from 6.6 to 9.7.CONCLUSIONS:
We used sensory testing to validate milk, egg white, and hazelnut recipes for use in DBPCFC. The validated recipes are easy to prepare in a clinical setting, provide the equivalent of 1 serving dose, and were liked by most participants.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pruebas Inmunológicas
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Proteínas del Huevo
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Hipersensibilidad a la Leche
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Hipersensibilidad al Huevo
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Hipersensibilidad a la Nuez
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Preparaciones de Plantas
/
Corylus
/
Proteínas de la Leche
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Investig Allergol Clin Immunol
Año:
2017
Tipo del documento:
Article
País de afiliación:
España