Targeting BAP1: a new paradigm for mesothelioma.
Lung Cancer
; 109: 145-146, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28342657
ABSTRACT
New treatment strategies for malignant pleural mesothelioma (MPM) are important. BAP1 mutations are present in 47-67% of the MPM tumors, making this a good target for treatment. Multiple functions of BAP1 are investigated in the preclinical situation. Due to many functions of BAP1, the phenotypic effect of BAP1 is diverse. Preclinical data on inhibitors reversing these phenotypic effects are promising. However, the mechanism of BAP1 is not fully elucidated yet and further research about the mechanism and possible inhibitors is necessary.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas Supresoras de Tumor
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Ubiquitina Tiolesterasa
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Mesotelioma
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Mutación
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Antineoplásicos
Idioma:
En
Revista:
Lung Cancer
Año:
2017
Tipo del documento:
Article