Median nerve stimulation prevents atrial electrical remodelling and inflammation in a canine model with rapid atrial pacing.
Europace
; 20(4): 712-718, 2018 04 01.
Article
en En
| MEDLINE
| ID: mdl-28379329
ABSTRACT
Aims:
Studies have shown that stellate ganglion nerve activity has association with atrial electrical remodelling and atrial fibrillation (AF) inducibility, while median nerve stimulation (MNS) decreases cardiac sympathetic drive. In this study, we tested the hypothesis that MNS suppresses atrial electrical remodelling and AF vulnerability. Methods andresults:
The atrial effective refractory period (AERP) and AF inducibility at baseline and after 3 h of rapid atrial pacing were determined in dogs undergoing MNS (n = 7), MNS+ application of methyllycaconitine (n = 7) or sham procedure (n = 6). Then, the levels of tumour necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and acetylcholine (Ach) in the plasma and atrial tissues were measured. The control dogs (n = 4) were assigned to measure atrial inflammation cytokines. Short-term rapid atrial pacing induced shortening of the AERP, an increase in AERP dispersion, and an increase AF vulnerability in the sham dogs, which were all suppressed by MNS. Levels of TNF-a and IL-6 were higher, and Ach levels were lower in the left and the right atrium in the sham dogs than in the MNS dogs. Methyllycaconitine blunted the effects of MNS on the AERP, AERP dispersion, the AF vulnerability, and TNF-a and IL-6 levels in the atrium, but had no impact on the levels of Ach.Conclusions:
The effects of MNS on atrial electrical remodelling and AF inducibility might be associated with the cholinergic anti-inflammatory pathway.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
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Sistema Nervioso Autónomo
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Estimulación Cardíaca Artificial
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Terapia por Estimulación Eléctrica
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Mediadores de Inflamación
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Remodelación Atrial
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Atrios Cardíacos
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Frecuencia Cardíaca
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Nervio Mediano
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Europace
Año:
2018
Tipo del documento:
Article