Prognostic Effect of the Dose of Loop Diuretic Over 5 Years in Chronic Heart Failure.
J Card Fail
; 23(8): 589-593, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-28390907
ABSTRACT
BACKGROUND:
High diuretic doses in chronic heart failure (HF) are potentially deleterious. We assessed the effect of dynamic furosemide dose on all-cause mortality among HF ambulatory patients. METHODS ANDRESULTS:
A cohort of 560 ambulatory patients from an outpatient clinic specialized in HF, with median age 70 years, 67% male, and 89% with moderate-severely reduced ejection fraction, was retrospectively followed for up to 5 years. Dynamic furosamide exposure was categorized as low (0-59 mg/d), medium (60-119 mg/d), high (120-159 mg/d), and very high (≥160 mg/d). Extended Cox models were used to estimate the association between time-varying diuretic dose and mortality. A dose-dependent crude association between higher doses of furosemide and death (hazard ratio [HR] = 1.34, 95% confidence interval (CI) 1.06-2.16; HR = 2.09, 95% CI 1.54-2.84, for high and very high dose, respectively) was totally explained by patients' characteristics and disease severity indicators (adjusted HR = 0.94, 95% CI 0.63-1.38; HR = 1.10, 95% CI 0.79-1.55, for high and very high dose, respectively).CONCLUSION:
In this context, higher doses of diuretic did not impair survival, but rather indicated greater severity of the patient's condition.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores del Simportador de Cloruro Sódico y Cloruro Potásico
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Furosemida
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Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Card Fail
Año:
2017
Tipo del documento:
Article