Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study.
Prostaglandins Leukot Essent Fatty Acids
; 119: 38-44, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28410668
ABSTRACT
Low omega-3 polyunsaturated fatty acid (PUFA) levels are seen in major depression. We examined effects of six weeks of fish oil supplementation on clinical characteristics in 16 patients with symptomatic major depressive disorder, and tested plasma phospholipid levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as correlates of clinical response. Depression symptoms improved after supplementation (p=0.007). The reduction in depression severity was not predicted by baseline PUFA levels but did exhibit a relationship with endpoint PUFAs, correlating negatively with DHA as a percentage of plasma phospholipids (DHA%; R2=0.60, p=0.004), adjusting for endpoint EPA%; and correlating positively with endpoint EPA% (R2=0.58, p=0.007), adjusting for endpoint DHA%. Thus, the higher the proportion of DHA to EPA, the greater the reduction in depression severity (r=-0.43, p=0.097). Five patients showed a decrease of >50% on the 17-item Hamilton Depression Rating Scale and a final score <7 and were thus not only responders but met standard criteria for remission, and were distinguished from non-responders by higher levels of DHA% (p=0.03). This pilot study suggests that post-supplementation DHA% levels may be a necessary target for antidepressant response to fish oil, and that this may depend to some extent on the efficacy of EPA conversion to DHA.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aceites de Pescado
/
Ácido Eicosapentaenoico
/
Ácidos Docosahexaenoicos
/
Trastorno Depresivo Mayor
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Año:
2017
Tipo del documento:
Article