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Desalted Duck Egg White Peptides Promote Calcium Uptake and Modulate Bone Formation in the Retinoic Acid-Induced Bone Loss Rat and Caco-2 Cell Model.
Hou, Tao; Liu, Yanshuang; Kolba, Nikolai; Guo, Danjun; He, Hui.
Afiliación
  • Hou T; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. mrhoutao@webmail.hzau.edu.cn.
  • Liu Y; Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. mrhoutao@webmail.hzau.edu.cn.
  • Kolba N; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. ysliu@webmail.hzau.edu.cn.
  • Guo D; Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. ysliu@webmail.hzau.edu.cn.
  • He H; USDA-ARS, Robert W. Holley Center for Agriculture and Health, Cornell University, Ithaca, NY 14850, USA. nk598@cornell.edu.
Nutrients ; 9(5)2017 May 12.
Article en En | MEDLINE | ID: mdl-28498349
Desalted duck egg white peptides (DPs) have been proven to promote calcium uptake in Caco-2 cells and rats treated with a calcium-deficient diet. The retinoic acid-induced bone loss model was used to evaluate the effect of DPs on calcium absorption and bone formation. Three-month-old Wistar female rats were treated with 0.9% saline, DPs (800 mg/kg), or alendronate (5 mg/kg) for three weeks immediately after retinoic acid treatment (80 mg/kg) once daily for two weeks. The model group was significantly higher in serum bone alkaline phosphatase than the other three groups (p < 0.05), but lower in calcium absorption rate, serum osteocalcin, bone weight index, bone calcium content, bone mineral density, and bone max load. After treatment with DPs or alendronate, the absorption rate increased and some serum and bone indices recovered. The morphology results indicated bone tissue form were ameliorated and numbers of osteoclasts decreased after supplementation with DPs or alendronate. The in vitro study showed that the transient receptor potential vanilloid 6 (TRPV6) calcium channel was the main transport pathway of both DPs and Val-Ser-Glu-Glu peptitde (VSEE), which was identified from DPs. Our results indicated that DPs could be a promising alternative to current therapeutic agents for bone loss because of the promotion of calcium uptake and regulation of bone formation.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteogénesis / Péptidos / Tretinoina / Enfermedades Óseas Metabólicas / Calcio / Clara de Huevo Tipo de estudio: Prognostic_studies Idioma: En Revista: Nutrients Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteogénesis / Péptidos / Tretinoina / Enfermedades Óseas Metabólicas / Calcio / Clara de Huevo Tipo de estudio: Prognostic_studies Idioma: En Revista: Nutrients Año: 2017 Tipo del documento: Article País de afiliación: China