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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11ß hydroxysteroid dehydrogenase type 1 inhibitor.
Zhuang, Linghang; Tice, Colin M; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Ye, Yuan-Jie; Singh, Suresh B; Lindblom, Peter; McKeever, Brian M; Krosky, Paula M; Zhao, Yi; Lala, Deepak; Kruk, Barbara A; Meng, Shi; Howard, Lamont; Johnson, Judith A; Bukhtiyarov, Yuri; Panemangalore, Reshma; Guo, Joan; Guo, Rong; Himmelsbach, Frank; Hamilton, Bradford; Schuler-Metz, Annette; Schauerte, Heike; Gregg, Richard; McGeehan, Gerard M; Leftheris, Katerina; Claremon, David A.
Afiliación
  • Zhuang L; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: linghang_zhuang@yahoo.com.
  • Tice CM; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Xu Z; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Zhao W; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Cacatian S; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Ye YJ; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Singh SB; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Lindblom P; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • McKeever BM; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Krosky PM; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Zhao Y; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Lala D; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Kruk BA; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Meng S; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Howard L; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Johnson JA; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Bukhtiyarov Y; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Panemangalore R; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Guo J; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Guo R; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Himmelsbach F; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany.
  • Hamilton B; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany.
  • Schuler-Metz A; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany.
  • Schauerte H; Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany.
  • Gregg R; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • McGeehan GM; Biology, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Leftheris K; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Claremon DA; Medicinal Chemistry, Vitae Pharmaceuticals, Inc, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
Bioorg Med Chem ; 25(14): 3649-3657, 2017 07 15.
Article en En | MEDLINE | ID: mdl-28528082
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxazinas / Piridonas / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 Idioma: En Revista: Bioorg Med Chem Año: 2017 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxazinas / Piridonas / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 Idioma: En Revista: Bioorg Med Chem Año: 2017 Tipo del documento: Article