ß-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1&#945;/ATF6 pathway.

Liu, Ying; Jiang, Zi-Yu; Zhou, Yuan-Li; Qiu, Hui-Hui; Wang, Gang; Luo, Yi; Liu, Jing-Bing; Liu, Xiong-Wei; Bu, Wei-Quan; Song, Jie; Cui, Li; Jia, Xiao-Bin; Feng, Liang

ß-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway.

Liu, Ying; Jiang, Zi-Yu; Zhou, Yuan-Li; Qiu, Hui-Hui; Wang, Gang; Luo, Yi; Liu, Jing-Bing; Liu, Xiong-Wei; Bu, Wei-Quan; Song, Jie; Cui, Li; Jia, Xiao-Bin; Feng, Liang.

Afiliación

Liu Y; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; School of Pharmacy, Anhui University of Chinese Medicine, Anhui Hefei 230038, PR China.
Jiang ZY; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Zhou YL; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China.
Qiu HH; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Wang G; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; School of Pharmacy, Anhui University of Chinese Medicine, Anhui Hefei 230038, PR China.
Luo Y; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Liu JB; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Liu XW; The Affiliated Jiangyin Hospital of Southeast University Medical Collage, Jiangyin 214400, Jiangsu, PR China.
Bu WQ; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Song J; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Cui L; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China.
Jia XB; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China. Electronic address: jxiaobin2005@hot
Feng L; Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu Nanjing, 210028, PR China; Third School of Clinical Medical of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210028, PR China. Electronic address: wenmoxiushi@163.

Biomed Pharmacother ; 93: 490-497, 2017 Sep.

Article en En | MEDLINE | ID: mdl-28672279

Asunto(s)

Factor de Transcripción Activador 6/metabolismo; Apoptosis/efectos de los fármacos; Carcinoma de Pulmón de Células no Pequeñas/patología; Estrés del Retículo Endoplásmico/efectos de los fármacos; Endorribonucleasas/metabolismo; Neoplasias Pulmonares/patología; Proteínas Serina-Treonina Quinasas/metabolismo; Sesquiterpenos/farmacología; eIF-2 Quinasa/metabolismo; Células A549; Animales; Antineoplásicos Fitogénicos/farmacología; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Supervivencia Celular/efectos de los fármacos; Humanos; Neoplasias Pulmonares/metabolismo; Ratones Endogámicos C57BL; Modelos Biológicos; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Factores de Tiempo; Factor de Transcripción CHOP/metabolismo

Palabras clave

Apoptosis; Endoplasmic reticulum stress; Non-small-cell lung cancer; ß-elemene

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos / Proteínas Serina-Treonina Quinasas / Apoptosis / Carcinoma de Pulmón de Células no Pequeñas / EIF-2 Quinasa / Endorribonucleasas / Factor de Transcripción Activador 6 / Estrés del Retículo Endoplásmico / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomed Pharmacother Año: 2017 Tipo del documento: Article

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