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High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Zhou, Ting; Tan, Lei; Cederquist, Gustav Y; Fan, Yujie; Hartley, Brigham J; Mukherjee, Suranjit; Tomishima, Mark; Brennand, Kristen J; Zhang, Qisheng; Schwartz, Robert E; Evans, Todd; Studer, Lorenz; Chen, Shuibing.
Afiliación
  • Zhou T; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Tan L; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Cederquist GY; The Center for Stem Cell Biology, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA; Weill-Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.
  • Fan Y; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Hartley BJ; Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
  • Mukherjee S; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Tomishima M; The Center for Stem Cell Biology, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA.
  • Brennand KJ; Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
  • Zhang Q; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, 125 Mason Farm Road, Chapel Hill, NC 27599, USA.
  • Schwartz RE; Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Physiology Biophysics and Systems Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Evans T; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
  • Studer L; The Center for Stem Cell Biology, New York, NY 10065, USA; Developmental Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA. Electronic address: studerl@mskcc.org.
  • Chen S; Department of Surgery, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. Electronic address: shc2034@med.cornell.edu.
Cell Stem Cell ; 21(2): 274-283.e5, 2017 08 03.
Article en En | MEDLINE | ID: mdl-28736217
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Encéfalo / Organoides / Evaluación Preclínica de Medicamentos / Células Madre Pluripotentes Inducidas / Células-Madre Neurales / Virus Zika / Infección por el Virus Zika Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Cell Stem Cell Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Encéfalo / Organoides / Evaluación Preclínica de Medicamentos / Células Madre Pluripotentes Inducidas / Células-Madre Neurales / Virus Zika / Infección por el Virus Zika Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Cell Stem Cell Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos