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Neuromuscular Electrical Stimulation and Anabolic Signaling in Patients with Stroke.
Mettler, Joni A; Bennett, Sydney M; Doucet, Barbara M; Magee, Dillon M.
Afiliación
  • Mettler JA; Department of Health and Human Performance, Texas State University, San Marcos, Texas. Electronic address: jam388@txstate.edu.
  • Bennett SM; Department of Health and Human Performance, Texas State University, San Marcos, Texas.
  • Doucet BM; Department of Occupational Therapy, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
  • Magee DM; Department of Health and Human Performance, Texas State University, San Marcos, Texas.
J Stroke Cerebrovasc Dis ; 26(12): 2954-2963, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28823492
INTRODUCTION: Stroke results in limited ability to produce voluntary muscle contraction and movement on one side of the body, leading to further muscle wasting and weakness. Neuromuscular electrical stimulation is often used to facilitate involuntary muscle contraction; however, the effect of neuromuscular electrical stimulation on muscle growth and strengthening processes in hemiparetic muscle is not clear. This study examined the skeletal muscle anabolic response of an acute bout of neuromuscular electrical stimulation in individuals with chronic stroke and healthy older adults. METHODS: Eleven individuals (59.8 ± 2.7 years old) were divided into a chronic stroke group (n = 5) and a healthy older adult control group (n = 6). Muscle biopsies were obtained before and after stimulation from the vastus lateralis of the hemiparetic leg for the stroke group and the right leg for the control group. The neuromuscular electrical stimulation protocol consisted of a 60-minute, intermittent stimulation train at 60 Hz. Phosphorylation of mammalian target of rapamycin and ribosomal protein S6 kinase beta-1 were analyzed by Western blot. FINDINGS: An acute bout of neuromuscular electrical stimulation increased phosphorylation of mammalian target of rapamycin (stroke: 56.0%; control: 51.4%; P = .002) and ribosomal protein S6 kinase beta-1 (stroke: 131.2%; control: 156.3%; P = .002) from resting levels to post-neuromuscular electrical stimulation treatment, respectively. Phosphorylated protein content was similar between stroke and control groups at both time points. CONCLUSION: Findings suggest that paretic muscles of patients with chronic stroke may maintain ability to stimulate protein synthesis machinery in response to neuromuscular electrical stimulation.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paresia / Transducción de Señal / Terapia por Estimulación Eléctrica / Accidente Cerebrovascular / Músculo Cuádriceps / Contracción Muscular / Unión Neuromuscular Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies / Risk_factors_studies Idioma: En Revista: J Stroke Cerebrovasc Dis Año: 2017 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paresia / Transducción de Señal / Terapia por Estimulación Eléctrica / Accidente Cerebrovascular / Músculo Cuádriceps / Contracción Muscular / Unión Neuromuscular Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies / Risk_factors_studies Idioma: En Revista: J Stroke Cerebrovasc Dis Año: 2017 Tipo del documento: Article