Pharmacodynamics of the Orotomides against <i>Aspergillus fumigatus</i>: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease.

Hope, William W; McEntee, Laura; Livermore, Joanne; Whalley, Sarah; Johnson, Adam; Farrington, Nicola; Kolamunnage-Dona, Ruwanthi; Schwartz, Julie; Kennedy, Anthony; Law, Derek; Birch, Michael; Rex, John H

Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease.

Hope, William W; McEntee, Laura; Livermore, Joanne; Whalley, Sarah; Johnson, Adam; Farrington, Nicola; Kolamunnage-Dona, Ruwanthi; Schwartz, Julie; Kennedy, Anthony; Law, Derek; Birch, Michael; Rex, John H.

Afiliación

Hope WW; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom william.hope@liverpool.ac.uk.
McEntee L; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Livermore J; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Whalley S; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Johnson A; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Farrington N; Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Kolamunnage-Dona R; Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Schwartz J; Charles River Laboratories, Davis, California, USA.
Kennedy A; F2G Ltd., Eccles, United Kingdom.
Law D; F2G Ltd., Eccles, United Kingdom.
Birch M; F2G Ltd., Eccles, United Kingdom.
Rex JH; F2G Ltd., Eccles, United Kingdom.

mBio ; 8(4)2017 08 22.

Article en En | MEDLINE | ID: mdl-28830945

Asunto(s)

Acetamidas/farmacología; Antifúngicos/farmacología; Aspergillus fumigatus/efectos de los fármacos; Farmacorresistencia Fúngica Múltiple; Aspergilosis Pulmonar Invasiva/tratamiento farmacológico; Piperazinas/farmacología; Pirimidinas/farmacología; Pirroles/farmacología; Acetamidas/farmacocinética; Acetamidas/uso terapéutico; Acetamidas/toxicidad; Animales; Antifúngicos/farmacocinética; Antifúngicos/uso terapéutico; Antifúngicos/toxicidad; Modelos Animales de Enfermedad; Descubrimiento de Drogas; Galactosa/análogos & derivados; Aspergilosis Pulmonar Invasiva/microbiología; Mananos/sangre; Ratones; Pruebas de Sensibilidad Microbiana; Neutropenia; Piperazinas/farmacocinética; Piperazinas/uso terapéutico; Piperazinas/toxicidad; Neumonía/tratamiento farmacológico; Neumonía/microbiología; Pirimidinas/farmacocinética; Pirimidinas/uso terapéutico; Pirimidinas/toxicidad; Pirroles/farmacocinética; Pirroles/uso terapéutico; Pirroles/toxicidad; Conejos; Triazoles/administración & dosificación; Triazoles/farmacocinética; Triazoles/farmacología; Triazoles/uso terapéutico

Palabras clave

Aspergillus fumigatus; antifungal agents; antifungal resistance; antifungal susceptibility testing; drug discovery; laboratory animals; pharmacodynamics; pharmacokinetics; pharmacology; pneumonia; pulmonary infection

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Piperazinas / Pirimidinas / Pirroles / Aspergillus fumigatus / Farmacorresistencia Fúngica Múltiple / Aspergilosis Pulmonar Invasiva / Acetamidas / Antifúngicos Idioma: En Revista: MBio Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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