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Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.
Höllerhage, Matthias; Moebius, Claudia; Melms, Johannes; Chiu, Wei-Hua; Goebel, Joachim N; Chakroun, Tasnim; Koeglsperger, Thomas; Oertel, Wolfgang H; Rösler, Thomas W; Bickle, Marc; Höglinger, Günter U.
Afiliación
  • Höllerhage M; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany.
  • Moebius C; Department of Neurology, Technical University of Munich, D-81675, Munich, Germany.
  • Melms J; HT-Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics, D-01307, Dresden, Germany.
  • Chiu WH; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany.
  • Goebel JN; Department of Neurology, Technical University of Munich, D-81675, Munich, Germany.
  • Chakroun T; Department of Neurology, University of Marburg, D-35043, Marburg, Germany.
  • Koeglsperger T; Department of Neurology, University of Marburg, D-35043, Marburg, Germany.
  • Oertel WH; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany.
  • Rösler TW; Munich Cluster for Systems Neurology (SyNergy), D-81337, Munich, Germany.
  • Bickle M; Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), D-81377, Munich, Germany.
  • Höglinger GU; Department of Neurology, Ludwig Maximilian University of Munich, D-81377, Munich, Germany.
Sci Rep ; 7(1): 11469, 2017 09 13.
Article en En | MEDLINE | ID: mdl-28904388
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfodiesterasa I / Inhibidores Enzimáticos / Alfa-Sinucleína / Descubrimiento de Drogas / Agregación Patológica de Proteínas Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfodiesterasa I / Inhibidores Enzimáticos / Alfa-Sinucleína / Descubrimiento de Drogas / Agregación Patológica de Proteínas Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Alemania