Discovery of highly potent, selective, covalent inhibitors of JAK3.
Bioorg Med Chem Lett
; 27(20): 4622-4625, 2017 10 15.
Article
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| MEDLINE
| ID: mdl-28927786
ABSTRACT
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteínas Quinasas
/
Janus Quinasa 3
Idioma:
En
Revista:
Bioorg Med Chem Lett
Año:
2017
Tipo del documento:
Article