Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.

Valenti, Daniela; Rossi, Leonardo; Marzulli, Domenico; Bellomo, Francesco; De Rasmo, Domenico; Signorile, Anna; Vacca, Rosa Anna

Valenti, Daniela; Rossi, Leonardo; Marzulli, Domenico; Bellomo, Francesco; De Rasmo, Domenico; Signorile, Anna; Vacca, Rosa Anna.

Afiliación

Valenti D; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, Italy. Electronic address: d.valenti@ibiom.cnr.it.
Rossi L; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Marzulli D; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, Italy.
Bellomo F; Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital - IRCCS, Rome, Italy.
De Rasmo D; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, Italy.
Signorile A; Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Italy.
Vacca RA; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, Italy. Electronic address: r.vacca@ibiom.cnr.it.

Biochim Biophys Acta Mol Basis Dis ; 1863(12): 3117-3127, 2017 12.

Article en En | MEDLINE | ID: mdl-28939434

Asunto(s)

Síndrome de Down/metabolismo; Síndrome de Down/patología; Dinaminas/metabolismo; Mitocondrias/metabolismo; Dinámicas Mitocondriales/fisiología; Neurogénesis/fisiología; Animales; Proliferación Celular; Modelos Animales de Enfermedad; Dinaminas/antagonistas & inhibidores; Metabolismo Energético; GTP Fosfohidrolasas/metabolismo; Hipocampo/metabolismo; Hipocampo/patología; Ratones; Atrofia Óptica Autosómica Dominante/metabolismo; Quinazolinonas/antagonistas & inhibidores; Quinazolinonas/metabolismo

Palabras clave

Down syndrome; Drp1; Hippocampal neurogenesis; Mdivi-1; Mitochondrial dysfunction; Mitochondrial network

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_energeticas / Bioenergetica Asunto principal: Síndrome de Down / Dinaminas / Neurogénesis / Dinámicas Mitocondriales / Mitocondrias Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2017 Tipo del documento: Article

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