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Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.
Kumazoe, Motofumi; Yamashita, Mai; Nakamura, Yuki; Takamatsu, Kanako; Bae, Jaehoon; Yamashita, Shuya; Yamada, Shuhei; Onda, Hiroaki; Nojiri, Takashi; Kangawa, Kenji; Tachibana, Hirofumi.
Afiliación
  • Kumazoe M; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Yamashita M; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, 565-8565, Japan.
  • Nakamura Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Takamatsu K; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Bae J; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Yamashita S; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Yamada S; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Onda H; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan; and.
  • Nojiri T; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, 565-8565, Japan.
  • Kangawa K; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, 565-8565, Japan.
  • Tachibana H; Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, 565-8565, Japan.
J Immunol ; 199(9): 3261-3269, 2017 11 01.
Article en En | MEDLINE | ID: mdl-28954885
TLR signaling is critical to innate immune system regulation; however, aberrant TLR signaling is involved in several diseases, including insulin resistance, Alzheimer's disease, and tumor metastasis. Moreover, a recent study found that TLR-4 signaling pathway inhibition might be a target for the suppression of chronic inflammatory disorders. In this article, we show that the green tea polyphenol epigallocatechin-3-O-gallate (EGCG) increases the expression of Toll interacting protein, a strong inhibitor of TLR4 signaling, by suppressing the expression of E74-like ETS transcription factor 1 (Elf-1). A mechanistic study revealed that EGCG suppressed Elf-1 expression via protein phosphatase 2A/cyclic GMP (cGMP)-dependent mechanisms. We also confirmed that orally administered EGCG and a cGMP inducer upregulated Toll interacting protein expression, increased intracellular levels of cGMP in macrophages, and suppressed Elf-1 expression. These data support EGCG and a cGMP inducer as potential candidate suppressors of TLR4 signaling.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Té / Factores de Transcripción / Proteínas Nucleares / Sistemas de Mensajero Secundario / Catequina / Regulación hacia Arriba / Péptidos y Proteínas de Señalización Intracelular / Proteínas de Unión al ADN Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Té / Factores de Transcripción / Proteínas Nucleares / Sistemas de Mensajero Secundario / Catequina / Regulación hacia Arriba / Péptidos y Proteínas de Señalización Intracelular / Proteínas de Unión al ADN Idioma: En Revista: J Immunol Año: 2017 Tipo del documento: Article