Stevia rebaudiana targeting α-amylase: An in-vitro and in-silico mechanistic study.
Nat Prod Res
; 33(4): 548-552, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-29072099
ABSTRACT
Diabetes mellitus (DM) is the fastest growing metabolic disorder in the world. Recently, more attention is paid to the study of natural products due to side effects of synthetic drugs. Stevia rebaudiana (Bertoni) is considered an encouraging starting point for the antidiabetic lead development. In the present study, the in vitro α-amylase inhibitory activity of the extracts of S. rebaudiana is investigated. In order to understand the molecular mechanism and future pharmacophore development, in silico study of secondary metabolites isolated from S. rebaudiana was carried out. Results indicated that water extract shows highest α-amylase inhibitory activity as compared to other extracts. Moreover, compound 20 (rebaudioside A) which has been previously reported and isolated from water extract showed the impressive binding profile with α-amylase. Therefore, our study suggests that S. rebaudiana could be used in the development of therapeutic drugs for the treatment of diabetes.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Stevia
/
Alfa-Amilasas
Idioma:
En
Revista:
Nat Prod Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
India