The inhibitory effects of ß-caryophyllene, ß-caryophyllene oxide and &#945;-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro.

Nguyen, Linh Thuy; Myslivecková, Zuzana; Szotáková, Barbora; Spicáková, Alena; Lnenicková, Katerina; Ambroz, Martin; Kubícek, Vladimír; Krasulová, Kristýna; Anzenbacher, Pavel; Skálová, Lenka

The inhibitory effects of ß-caryophyllene, ß-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro.

Nguyen, Linh Thuy; Myslivecková, Zuzana; Szotáková, Barbora; Spicáková, Alena; Lnenicková, Katerina; Ambroz, Martin; Kubícek, Vladimír; Krasulová, Kristýna; Anzenbacher, Pavel; Skálová, Lenka.

Afiliación

Nguyen LT; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: nguyenli@faf.cuni.cz.
Myslivecková Z; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: zuzka.mysliveckova@seznam.cz.
Szotáková B; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: szotako@faf.cuni.cz.
Spicáková A; Department of Pharmacology and Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Hnevotínská 3, 77515 Olomouc, Czech Republic. Electronic address: alena.spicakova@upol.cz.
Lnenicková K; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: lnenickk@faf.cuni.cz.
Ambroz M; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: ambrozm@faf.cuni.cz.
Kubícek V; Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: kubicek@faf.cuni.cz.
Krasulová K; Department of Pharmacology and Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Hnevotínská 3, 77515 Olomouc, Czech Republic. Electronic address: Kkrasulova@seznam.cz.
Anzenbacher P; Department of Pharmacology and Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Hnevotínská 3, 77515 Olomouc, Czech Republic. Electronic address: anzen@seznam.cz.
Skálová L; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. Electronic address: lenka.skalova@faf.cuni.cz.

Chem Biol Interact ; 278: 123-128, 2017 Dec 25.

Article en En | MEDLINE | ID: mdl-29074051

Asunto(s)

Antiinflamatorios no Esteroideos/metabolismo; Citocromo P-450 CYP3A/metabolismo; Microsomas Hepáticos/enzimología; Sesquiterpenos/metabolismo; Animales; Antiinflamatorios no Esteroideos/química; Citocromo P-450 CYP1A2/química; Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP3A/química; Humanos; Concentración 50 Inhibidora; Cinética; Hígado/enzimología; Masculino; Sesquiterpenos Monocíclicos; Sesquiterpenos Policíclicos; Ratas; Ratas Wistar; Sesquiterpenos/química

Palabras clave

Drug-sesquiterpene interactions; Enzyme inhibition; Sesquiterpenes; cytochromes P450

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos / Microsomas Hepáticos / Antiinflamatorios no Esteroideos / Citocromo P-450 CYP3A Idioma: En Revista: Chem Biol Interact Año: 2017 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google