Design and Application of a DNA-Encoded Macrocyclic Peptide Library.
ACS Chem Biol
; 13(1): 53-59, 2018 01 19.
Article
en En
| MEDLINE
| ID: mdl-29185700
ABSTRACT
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Proteínas Virales
/
Biblioteca de Péptidos
/
Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau
Idioma:
En
Revista:
ACS Chem Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos