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Design and Application of a DNA-Encoded Macrocyclic Peptide Library.
Zhu, Zhengrong; Shaginian, Alex; Grady, LaShadric C; O'Keeffe, Thomas; Shi, Xiangguo E; Davie, Christopher P; Simpson, Graham L; Messer, Jeffrey A; Evindar, Ghotas; Bream, Robert N; Thansandote, Praew P; Prentice, Naomi R; Mason, Andrew M; Pal, Sandeep.
Afiliación
  • Zhu Z; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Shaginian A; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Grady LC; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • O'Keeffe T; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Shi XE; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Davie CP; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Simpson GL; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
  • Messer JA; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Evindar G; GlaxoSmithKline , 200 Cambridge Park Dr., Cambridge, Massachusetts 02140, United States.
  • Bream RN; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
  • Thansandote PP; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
  • Prentice NR; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
  • Mason AM; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
  • Pal S; GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ACS Chem Biol ; 13(1): 53-59, 2018 01 19.
Article en En | MEDLINE | ID: mdl-29185700
ABSTRACT
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Proteínas Virales / Biblioteca de Péptidos / Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau Idioma: En Revista: ACS Chem Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Proteínas Virales / Biblioteca de Péptidos / Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau Idioma: En Revista: ACS Chem Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos