Increased serum protein levels by Yuanshi Shengmai Chenggu Tablet in treatment of avascular osteonecrosis of the femoral head.
Mol Med Rep
; 17(2): 2121-2126, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29207081
ABSTRACT
The traditional Chinese medicine (TCM) Yuanshi Shengmai Chenggu Tablet is used for treating the common orthopedic disease, hormoneinduced avascular necrosis of the femoral head (ANFH) in China. However, its underlying mechanism and the changes induced in the treatment of ANFH remain to be fully elucidated. In the present study, through the use of isobaric Tag for Relative and Absolute Quantitation and multiple reaction monitoring quantifications, corticosteroidinduced femoral head necrosis and the effects of treatment with Yuanshi Shengmai Chenggu Tablet were examined. The aim was to identify serum proteins, which may be potential serum markers for the early clinical diagnosis of ANFH, and maybe used to develop more rapid and convenient detection strategies. A total of five proteins were identified, comprising Ig mu chain C region, keratin, type I cytoskeletal 9, properdin, apolipoprotein AIV, and IQ and AAA domaincontaining protein 1. The expression levels of all five proteins were lower in ANFH and were higher following TCM treatment. These findings were confirmed using ELISA and western blot analysis.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
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Medicina_china
Asunto principal:
Proteínas Sanguíneas
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Biomarcadores
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Necrosis de la Cabeza Femoral
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Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
Idioma:
En
Revista:
Mol Med Rep
Año:
2018
Tipo del documento:
Article