A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage.

Reddy, B Uma; Mullick, Ranajoy; Kumar, Anuj; Sharma, Geetika; Bag, Paromita; Roy, Chaitrali Laha; Sudha, Govindarajan; Tandon, Himani; Dave, Pratik; Shukla, Ashutosh; Srinivasan, Priyanka; Nandhitha, Madhusudhan; Srinivasan, Narayanaswamy; Das, Saumitra

Reddy, B Uma; Mullick, Ranajoy; Kumar, Anuj; Sharma, Geetika; Bag, Paromita; Roy, Chaitrali Laha; Sudha, Govindarajan; Tandon, Himani; Dave, Pratik; Shukla, Ashutosh; Srinivasan, Priyanka; Nandhitha, Madhusudhan; Srinivasan, Narayanaswamy; Das, Saumitra.

Afiliación

Reddy BU; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Mullick R; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Kumar A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Sharma G; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Bag P; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Roy CL; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Sudha G; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Tandon H; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Dave P; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Shukla A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Srinivasan P; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Nandhitha M; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.
Srinivasan N; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India.
Das S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India. Electronic address: sdas@iisc.ac.in.

Antiviral Res ; 150: 47-59, 2018 02.

Article en En | MEDLINE | ID: mdl-29224736

Asunto(s)

Glucósidos/farmacología; Hepacivirus/efectos de los fármacos; Hepacivirus/fisiología; Hepatitis C/metabolismo; Hepatitis C/virología; Taninos Hidrolizables/farmacología; Hígado/metabolismo; Hígado/virología; Animales; Antivirales/aislamiento & purificación; Antivirales/farmacología; Línea Celular; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Modelos Animales de Enfermedad; Expresión Génica; Genes Reporteros; Glucósidos/aislamiento & purificación; Hepatitis C/complicaciones; Hepatitis C/patología; Humanos; Taninos Hidrolizables/aislamiento & purificación; Hígado/efectos de los fármacos; Cirrosis Hepática; Ratones; NADPH Oxidasa 4/metabolismo; Estrés Oxidativo/efectos de los fármacos; Extractos Vegetales/aislamiento & purificación; Extractos Vegetales/farmacología; Ratas; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Factor de Crecimiento Transformador beta/metabolismo; Proteínas no Estructurales Virales/antagonistas & inhibidores; Proteínas no Estructurales Virales/metabolismo; Replicación Viral/efectos de los fármacos

Palabras clave

Antiviral; Hepatitis C virus; Oxidative stress; Small molecule inhibitor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hepatitis C / Hepacivirus / Taninos Hidrolizables / Glucósidos / Hígado Tipo de estudio: Prognostic_studies Idioma: En Revista: Antiviral Res Año: 2018 Tipo del documento: Article País de afiliación: India

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