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Antibacterial activity and virtual screening by molecular docking of lycorine from Pancratium foetidum Pom (Moroccan endemic Amaryllidaceae).
Bendaif, H; Melhaoui, A; Ramdani, M; Elmsellem, H; Douez, C; El Ouadi, Y.
Afiliación
  • Bendaif H; Laboratory of Macromolecular Organic Chemistry and Natural Products (URAC25), Faculty of Science, 60000 Oujda, Morocco. Electronic address: h.bendaif@ump.ac.ma.
  • Melhaoui A; Laboratory of Macromolecular Organic Chemistry and Natural Products (URAC25), Faculty of Science, 60000 Oujda, Morocco.
  • Ramdani M; Laboratory of Applied Analytical Chemistry Materials and Environment (LA2CME-URAC18), Faculty of Science, B.P. 717, 60000 Oujda, Morocco.
  • Elmsellem H; Laboratory of Applied Analytical Chemistry Materials and Environment (LA2CME-URAC18), Faculty of Science, B.P. 717, 60000 Oujda, Morocco.
  • Douez C; Université d'Artois, 62000, Arras, France.
  • El Ouadi Y; Laboratory of Applied Analytical Chemistry Materials and Environment (LA2CME-URAC18), Faculty of Science, B.P. 717, 60000 Oujda, Morocco. Electronic address: y.elouadi@ump.ac.ma.
Microb Pathog ; 115: 138-145, 2018 Feb.
Article en En | MEDLINE | ID: mdl-29253598
Lycorine is an alkaloid isolated from bulbs of Pancratium foetidum Pom Amaryllidaceae of the genus Lycoris. It has very strong pharmacodynamics properties and biological effects, among others, antimalarial, antiviral, antitumor, and anti-inflammatory. Lycorine has been identified and characterized by thin layer chromatography, IR and NMR (1H and 13C NMR, COZY, HMBC, HSQC and NOESY). The antibacterial activity of lycorine has been evaluated. Lycorine has a moderate antibacterial activity on the majority of strains studied, nevertheless it is more effective than Streptomycin and Ampicillin against bacteria: P. aeruginosa, En. cloacae. To confirm these results, it is necessary to use qualitative techniques and methods, etc… We performed a virtual docking ligand-lycorine protein screening study to predict and characterize their mode of interaction with the LpxC receptor. Docking results have shown that lycorine can interact with target amino residues studied by hydrogen and metal-ion bonds. In addition, the ADME-Tox profile study has shown that lycorine is all in agreement, either with Lipinski's critics or with the toxicity standards.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas Asunto principal: Fenantridinas / Extractos Vegetales / Alcaloides de Amaryllidaceae / Simulación del Acoplamiento Molecular / Amaryllidaceae / Antibacterianos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research / Screening_studies País/Región como asunto: Africa Idioma: En Revista: Microb Pathog Año: 2018 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas Asunto principal: Fenantridinas / Extractos Vegetales / Alcaloides de Amaryllidaceae / Simulación del Acoplamiento Molecular / Amaryllidaceae / Antibacterianos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research / Screening_studies País/Región como asunto: Africa Idioma: En Revista: Microb Pathog Año: 2018 Tipo del documento: Article