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Eating Green: Shining Light on the Use of Dietary Phytochemicals as a Modern Approach in the Prevention and Treatment of Head and Neck Cancers.
Eastham, Linda L; Howard, Candace M; Balachandran, Premalatha; Pasco, David S; Claudio, Pier Paolo.
Afiliación
  • Eastham LL; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, United States.
  • Howard CM; Department of Radiology, University of Mississippi Medical Center, Mississippi, United States.
  • Balachandran P; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, United States.
  • Pasco DS; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, United States.
  • Claudio PP; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, Mississippi, United States.
Curr Top Med Chem ; 18(3): 182-191, 2018.
Article en En | MEDLINE | ID: mdl-29332583
ABSTRACT
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC. Many of these compounds have been shown to elicit very potent anti-carcinogenic properties. While there are many compounds that have been studied, the compounds from two specific categories of phytochemicals, phenolics (resveratrol, EGCG, curcumin, quercetin, and honokiol) and glucosinolates (sulforaphane, PEITC and BITC), are emerging as potent and effective inhibitors of oral carcinogenesis. These compounds have been shown to inhibit HNSCC growth through a variety of mechanisms. Research has demonstrated that these compounds can regulate cancer cell proliferation through the regulation of multiple cell signaling pathways. They can impede cell cycle progression, induce differentiation and apoptosis, prevent angiogenesis, and inhibit cancer cell invasive and metastatic properties. They can protect normal cells during treatment and reduce the damage caused by chemotherapy and radiotherapy. This review aims to provide an overview of some of the most effective phytochemicals that have the potential to successfully prevent and treat head and neck squamous cell carcinoma.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Carcinoma de Células Escamosas / Fitoquímicos / Neoplasias de Cabeza y Cuello / Antineoplásicos Idioma: En Revista: Curr Top Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Carcinoma de Células Escamosas / Fitoquímicos / Neoplasias de Cabeza y Cuello / Antineoplásicos Idioma: En Revista: Curr Top Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos