Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol.
Brain Res Bull
; 139: 1-8, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29374603
Evidence has demonstrated iron accumulation in specific brain regions of patients suffering from neurodegenerative disorders, and this metal has been recognized as a contributing factor for neurodegeneration. Using an experimental model of brain iron accumulation, we have shown that iron induces severe memory deficits that are accompanied by oxidative stress, increased apoptotic markers, and decreased synaptophysin in the hippocampus of rats. The present study aims to characterize iron loading effects as well as to determine the molecular targets of cannabidiol (CBD), the main non-psychomimetic compound of Cannabis sativa, on mitochondria. Rats received iron in the neonatal period and CBD for 14â¯days in adulthood. Iron induced mitochondrial DNA (mtDNA) deletions, decreased epigenetic modulation of mtDNA, mitochondrial ferritin levels, and succinate dehydrogenase activity. CBD rescued mitochondrial ferritin and epigenetic modulation of mtDNA, and restored succinate dehydrogenase activity in iron-treated rats. These findings provide new insights into molecular targets of iron neurotoxicity and give support for the use of CBD as a disease modifying agent in the treatment of neurodegenerative diseases.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
ADN Mitocondrial
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Cannabidiol
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Enfermedades Neurodegenerativas
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Compuestos de Hierro Carbonilo
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Hipocampo
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Mitocondrias
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Brain Res Bull
Año:
2018
Tipo del documento:
Article