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Single-Center Experience with the Use of Teduglutide in Adult Patients with Short Bowel Syndrome.
Lam, Kwai; Schwartz, Lauren; Batisti, Jennifer; Iyer, Kishore R.
Afiliación
  • Lam K; Mount Sinai Medical Center, New York, NY, USA.
  • Schwartz L; Mount Sinai Medical Center, New York, NY, USA.
  • Batisti J; The Concord Medical Group, New York, NY, USA.
  • Iyer KR; Mount Sinai Medical Center, New York, NY, USA.
JPEN J Parenter Enteral Nutr ; 42(1): 225-230, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29505151
BACKGROUND: Teduglutide is a glucagon-like peptide 2 (GLP-2) analog that has been approved for the treatment of adult short bowel syndrome (SBS)-associated intestinal failure (IF; SBS-IF). Teduglutide increases villus height and crypt depth in the small bowel mucosa, promoting nutrition absorption and enteral independence from parenteral nutrition (PN). We aim to report our single-center experience with teduglutide in adult patients with SBS to provide real-world context to its use. METHOD: We conducted a retrospective analysis on patients managed within our tertiary-level intestinal rehabilitation program to identify patients with SBS-IF treated with teduglutide from 2009-2015. The current report includes all patients at our center who had any exposure to teduglutide, including those who received commercial drug after approval by the Food and Drug Administration (FDA) and outside the scope of clinical trials. RESULTS: A total of 18 patients were treated with teduglutide. Eleven patients (61%) achieved complete enteral independence from PN and/or intravenous fluids (IV) at a median time of 10 months (range: 3-36 months). PN/IV volume requirement was reduced in all patients except two. Ten of the 11 patients (91%) who achieved enteral autonomy had colon. All patients off PN/IV required additional oral vitamins and electrolyte supplementations. CONCLUSION: Our preliminary experience is consistent with prior reports of successful partial or complete weaning from PN/IV with teduglutide treatment in adult patients with SBS. The presence of colon appears to be favorable in obtaining enteral independence from PN/IV, regardless of residual small bowel length. Patients on teduglutide may remain at high risk of micronutrient deficiencies.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Síndrome del Intestino Corto / Fármacos Gastrointestinales Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: JPEN J Parenter Enteral Nutr Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Síndrome del Intestino Corto / Fármacos Gastrointestinales Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: JPEN J Parenter Enteral Nutr Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos