Your browser doesn't support javascript.
loading
Sex differences in hippocampal mineralocorticoid and glucocorticoid receptor mRNA expression in response to acute mate pair separation in zebra finches (Taeniopygia guttata).
Madison, Farrah N; Kesner, Andrew J; Alward, Beau A; Ball, Gregory F.
Afiliación
  • Madison FN; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218.
  • Kesner AJ; Department of Psychology, University of Maryland, College Park, Maryland 20742.
  • Alward BA; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218.
  • Ball GF; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218.
Hippocampus ; 28(10): 698-706, 2018 10.
Article en En | MEDLINE | ID: mdl-29663559
Mate separation has been shown to mediate changes in physiological and behavioral processes via activation of the hypothalamo-pituitary-adrenal (HPA) axis in both mammalian and avian species. To elucidate the neural mechanisms associated with changes in the HPA axis in response to social stress, we investigated the effects of mate pair separation on circulating corticosterone concentrations as well as gene expression levels of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), and corticotropin releasing hormone (CRH) in the hypothalamus and hippocampus of both male and female zebra finches, a species that forms strong pair bonds. Zebra finches (Taeniopygia guttata) were housed three to a cage (a mated pair plus a stimulus female), and were assigned to one of three new housing treatment groups: (1) male or female removed from their respective mate and placed in a cage with a new opposite sex conspecific and stimulus female (2) male or female that remained with their mate, but a new stimulus female was introduced, or (3) the subjects were handled but not separated from their mate or the stimulus female. After 48 hr in the new housing condition, we observed significant increases in plasma corticosterone concentrations in response to both mate pair and stimulus female separation. No significant differences in MR, GR, or CRH mRNA expression in the hypothalamus were observed in response to any treatment for both males and females. Females exhibited a significant up regulation in hippocampal MR, but not GR mRNA, whereas males exhibited a significant down regulation of both hippocampal MR and GR mRNA in response to mate pair separation. Thus, the hippocampus appears to play a key role in regulating sex specific responses to social stressors.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aislamiento Social / Estrés Psicológico / ARN Mensajero / Receptores de Glucocorticoides / Caracteres Sexuales / Receptores de Mineralocorticoides / Hipocampo Idioma: En Revista: Hippocampus Año: 2018 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aislamiento Social / Estrés Psicológico / ARN Mensajero / Receptores de Glucocorticoides / Caracteres Sexuales / Receptores de Mineralocorticoides / Hipocampo Idioma: En Revista: Hippocampus Año: 2018 Tipo del documento: Article