Astragalus polysaccharides exerts anti-infective activity by inducing human cathelicidin antimicrobial peptide LL-37 in respiratory epithelial cells.

Zhao, Lin; Tan, Shuai; Zhang, Hai; Liu, Peng; Tan, Yu-Zhu; Li, Jia-Chuan; Jia, Da; Shen, Xiao-Fei

Zhao, Lin; Tan, Shuai; Zhang, Hai; Liu, Peng; Tan, Yu-Zhu; Li, Jia-Chuan; Jia, Da; Shen, Xiao-Fei.

Afiliación

Zhao L; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
Tan S; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
Zhang H; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liu P; Shaanxi TASLY Plant Pharmaceutical Co Ltd., Shangluo, Shaanxi, China.
Tan YZ; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li JC; School of Pharmacy, Southwest Minzu University, Chengdu, China.
Jia D; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
Shen XF; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.

Phytother Res ; 32(8): 1521-1529, 2018 Aug.

Article en En | MEDLINE | ID: mdl-29672953

Asunto(s)

Astragalus propinquus/química; Catelicidinas/biosíntesis; Células Epiteliales/efectos de los fármacos; Antiinfecciosos; Péptidos Catiónicos Antimicrobianos; Línea Celular; Células Epiteliales/metabolismo; Humanos; Proteínas I-kappa B/metabolismo; Inhibidor NF-kappaB alfa; FN-kappa B/metabolismo; Fosforilación/efectos de los fármacos; Polisacáridos/farmacología; Factor de Transcripción ReIA; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

NF-κB signaling; anti-infective activity; astragalus polysaccharides; human cathelicidin antimicrobial peptide LL-37; p38 MAPK and JNK signaling

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astragalus propinquus / Células Epiteliales / Catelicidinas Idioma: En Revista: Phytother Res Año: 2018 Tipo del documento: Article País de afiliación: China

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