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Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human ß-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.
Mena-Barragán, Teresa; García-Moreno, M Isabel; Sevsek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I; Pieters, Roland J; Fernández, José M García; Mellet, Carmen Ortiz.
Afiliación
  • Mena-Barragán T; Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor García González 1, 41011 Sevilla, Spain. tmena@us.es.
  • García-Moreno MI; Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor García González 1, 41011 Sevilla, Spain. isagar@us.es.
  • Sevsek A; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. Sevsek@ke-instruments.com.
  • Okazaki T; Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago 680-8550, Japan. t-okazaki@med.tottori-u.ac.jp.
  • Nanba E; Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan. enanba@med.tottori-u.ac.jp.
  • Higaki K; Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan. kh4060@med.tottori-u.ac.jp.
  • Martin NI; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. n.i.martin@uu.nl.
  • Pieters RJ; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. r.j.pieters@uu.nl.
  • Fernández JMG; Instituto de Investigaciones Químicas (IIQ), CSIC-University of Sevilla, Avda. Americo Vespucio 49, 41092 Sevilla, Spain. jogarcia@iiq.csic.es.
  • Mellet CO; Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor García González 1, 41011 Sevilla, Spain. mellet@us.es.
Molecules ; 23(4)2018 04 17.
Article en En | MEDLINE | ID: mdl-29673163
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Chaperonas Moleculares / Inhibidores Enzimáticos / Iminoazúcares / Enfermedad de Gaucher / Glucosilceramidasa Idioma: En Revista: Molecules Año: 2018 Tipo del documento: Article País de afiliación: España
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Chaperonas Moleculares / Inhibidores Enzimáticos / Iminoazúcares / Enfermedad de Gaucher / Glucosilceramidasa Idioma: En Revista: Molecules Año: 2018 Tipo del documento: Article País de afiliación: España