Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease.
Am J Nephrol
; 47(5): 300-303, 2018.
Article
en En
| MEDLINE
| ID: mdl-29779025
ABSTRACT
We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglobin-phosphate and bowel-kidney phosphate regulation axis. Iron supplementation based on TmPi/GFR or earlier phosphate restriction based on TRP should be investigated in view of modifying clinical outcomes in CKD.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fosfatos
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Insuficiencia Renal Crónica
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Reabsorción Renal
/
Eliminación Renal
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Túbulos Renales
Tipo de estudio:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Idioma:
En
Revista:
Am J Nephrol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia