[Refractory allergic rhinitis serum levels of vitamin D and vitamin D calcium chewable therapeutic value].

Objective:To survey clinical efficacy of vitamin D calcium chewable tablets in the treatment of adults with refractory allergic rhinitis and investigate the level of 1,25-dihydroxyvitamin D3 in the patients' serum.Method:Sixty cases who were dignosed with adult refractory moderate to severe allergic in our hospital outpatient were admitted in our study from May 2014 to November 2015.Sixty cases of healthy people in our hospital medical center were selected as the control group,serum 1,25-dihydroxyvitamin D3 were detected in all patients and normal controls before the treatment.The control group were treated using fluticasone propionate nasal spray and left cetirizine while the experimental group were added with vitamin D calcium chewable tablets on the basis of the control group. Before treatment and after 2 or 4 weeks of treatment,a visual analog scale of the overall classification of nasal symptoms were used of and clinical symptoms evaluation.Result:Compared with healthy controls,the incidence of serum 1,25-dihydroxy vitamin D3 content is:(17.46±4.94)µg/L and the difference was statistically significant(P<0.0).The symptom scores of the treatment group and control group were significantly decreased before treatment and the difference had statistical significance(P<0.05).After four weeks of treatment,the experimental group of the symptom scores were lower than that of control group.The differences were statistically significant(P<0.05).Conclusion:Serum 1,25 dihydroxyvitamin D3 deficiency is a widespread phenonmenon in refractory allergic rhinitis.Vitamin D calcium chewable tables adjuvant treatment of allergic rhinitis is one of methods with safe,effective,and simple treatment.