Ultra-sonication-assisted silver nanoparticles using Panax ginseng root extract and their anti-cancer and antiviral activities.
J Photochem Photobiol B
; 188: 6-11, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-30176393
ABSTRACT
A simple, inexpensive ultra-sonication method was used to synthesize quasi spherical silver nanoparticles (AgNPs) with an aqueous extract from Panax ginseng roots. This method has the advantages of being completely eco-friendly and allows increased reaction rates, uniform dispersal of the nanoparticles in liquids, and effective breaking of aggregates. Biomolecules present in plant extracts are often used to reduce metal ions to nanoparticles in a single-step green synthesis route. The formation of the AgNPs was characterized using UV-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy- dispersive X-ray analysis (EDX), Fast Fourier Transform (FFT), and high-resolution transmission electron microscopy (HR-TEM). The formation of AgNPs (456â¯nm) was confirmed by UV-vis spectroscopy. HR-TEM analysis revealed that most of the AgNPs were quasi spherical with sizes ranging from approximately 5 to 15â¯nm. The crystalline nature of the AgNPs was confirmed by XRD, and the presence of elemental silver was confirmed by energy-dispersive X -ray analysis. The AgNPs showed dose-dependent cytotoxicity towards HeLa cells in vitro (3.88% at 0.005â¯M, 5.11% at 0.01â¯M, 7.52% at 0.015â¯M, 11.19% at 0.02â¯M, and 19.45% at 0.025â¯M) as revealed by sulforhodamine B assay. They were also shown to be virucidal against the influenza A virus (strain A/PR/8). Hence, the present facile, eco-friendly, and efficient method results in the synthesis of AgNPs that can act as an alternative biomaterial for future biomedical applications.
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Bases de datos:
MEDLINE
Medicinas Complementárias:
Homeopatia
Asunto principal:
Plata
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Extractos Vegetales
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Nanopartículas del Metal
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Panax
Idioma:
En
Revista:
J Photochem Photobiol B
Año:
2018
Tipo del documento:
Article