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Irilone from Red Clover ( Trifolium pratense) Potentiates Progesterone Signaling.
Lee, Jung-Ho; Dean, Matthew; Austin, Julia R; Burdette, Joanna E; Murphy, Brian T.
Afiliación
  • Lee JH; Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , 833 S. Wood Street , Chicago , Illinois 60612 , United States.
  • Dean M; Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , 833 S. Wood Street , Chicago , Illinois 60612 , United States.
  • Austin JR; Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , 833 S. Wood Street , Chicago , Illinois 60612 , United States.
  • Burdette JE; Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , 833 S. Wood Street , Chicago , Illinois 60612 , United States.
  • Murphy BT; Department of Medicinal Chemistry and Pharmacognosy and Center for Biomolecular Sciences, College of Pharmacy , University of Illinois at Chicago , 833 S. Wood Street , Chicago , Illinois 60612 , United States.
J Nat Prod ; 81(9): 1962-1967, 2018 09 28.
Article en En | MEDLINE | ID: mdl-30199256
ABSTRACT
The use of botanical dietary supplements is becoming increasingly popular for the alleviation of hormonal-based conditions such as hot flashes, premenstrual syndrome, and fertility. Estrogen and progesterone receptors (ER and PR) play an essential role in these processes. However, despite the fact that many therapies used to alleviate gynecological conditions act through PR-mediated mechanisms, few studies have investigated or identified any herbal natural product components that act on this receptor. In the current study, we used a progesterone response element (PRE)-luciferase (Luc) reporter assay to identify four phytoprogestins present in a standardized red clover ( Trifolium pratense) extract. We found that the component irilone (1) potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines. In these cancers, progesterone action is generally associated with positive outcomes; thus the potentiating effect of 1 may provide entirely new strategies for enhancing progesterone signaling as a means of mitigating conditions such as fibroids and endometriosis. Formononetin (3) and biochanin A (4) exhibited mixed agonist activity, while prunetin (2) acted only as an antagonist. Collectively, these results suggest that the effects of red clover extract repeatedly observed in cultured cells and the inverse correlation between risk of various cancers and flavonoid intake may be due, in part, to altered progesterone signaling.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Progesterona / Extractos Vegetales / Transducción de Señal / Trifolium / Isoflavonas Idioma: En Revista: J Nat Prod Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Progesterona / Extractos Vegetales / Transducción de Señal / Trifolium / Isoflavonas Idioma: En Revista: J Nat Prod Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos