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A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: result from a randomized study.
Damiot, Anthony; Demangel, Rémi; Noone, John; Chery, Isabelle; Zahariev, Alexandre; Normand, Sylvie; Brioche, Thomas; Crampes, François; de Glisezinski, Isabelle; Lefai, Etienne; Bareille, Marie Pierre; Chopard, Angèle; Drai, Jocelyne; Collin-Chavagnac, Delphine; Heer, Martina; Gauquelin-Koch, Guillemette; Prost, Michel; Simon, Patrick; Py, Guillaume; Blanc, Stéphane; Simon, Chantal; Bergouignan, Audrey; O'Gorman, Donal J.
Afiliación
  • Damiot A; Université de Strasbourg, Centre national de la recherche scientifique, Institut pluridisciplinaire Hubert Curien UMR 7178, Strasbourg , France.
  • Demangel R; Université de Montpellier, Institut National de la Recherche Agronomique, UMR866 34060, Dynamique Musculaire et Métabolisme, Montpellier , France.
  • Noone J; National Institute for Cellular Biotechnology and School of Health and Human Performance, Dublin City University , Dublin , Ireland.
  • Chery I; Université de Strasbourg, Centre national de la recherche scientifique, Institut pluridisciplinaire Hubert Curien UMR 7178, Strasbourg , France.
  • Zahariev A; Université de Strasbourg, Centre national de la recherche scientifique, Institut pluridisciplinaire Hubert Curien UMR 7178, Strasbourg , France.
  • Normand S; CARMEN, Centre de Recherche en Nutrition Humaine, Institut national de la santé et de la recherche médicale U1060/University of Lyon 1/INRA U1235 Lyon , France.
  • Brioche T; Université de Montpellier, Institut National de la Recherche Agronomique, UMR866 34060, Dynamique Musculaire et Métabolisme, Montpellier , France.
  • Crampes F; Institut national de la santé et de la recherche médicale, UMR 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases , Toulouse , France.
  • de Glisezinski I; Paul Sabatier University , Toulouse , France.
  • Lefai E; Institut national de la santé et de la recherche médicale, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases and University of Toulouse, Paul Sabatier University and Toulouse University Hospitals, Departments of Clinical Biochemistry and Sports Medicine , Toulo
  • Bareille MP; CARMEN, Centre de Recherche en Nutrition Humaine, Institut national de la santé et de la recherche médicale U1060/University of Lyon 1/INRA U1235 Lyon , France.
  • Chopard A; Institut de Médecine et de Physiologie Spatiales , Toulouse , France.
  • Drai J; Université de Montpellier, Institut National de la Recherche Agronomique, UMR866 34060, Dynamique Musculaire et Métabolisme, Montpellier , France.
  • Collin-Chavagnac D; CARMEN, Centre de Recherche en Nutrition Humaine, Institut national de la santé et de la recherche médicale U1060/University of Lyon 1/INRA U1235 Lyon , France.
  • Heer M; Laboratoire de Biochimie, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
  • Gauquelin-Koch G; CARMEN, Centre de Recherche en Nutrition Humaine, Institut national de la santé et de la recherche médicale U1060/University of Lyon 1/INRA U1235 Lyon , France.
  • Prost M; Laboratoire de Biochimie, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
  • Simon P; Institute of Nutritional and Food Sciences, University of Bonn , Bonn , Germany.
  • Py G; Centre National d'Etudes Spatiales , Paris , France.
  • Blanc S; Laboratoire de recherches appliquées Spiral/Kirial International, Couternon, France.
  • Simon C; Hôpital St-Joseph St-Luc, Lyon , France.
  • Bergouignan A; Université de Montpellier, Institut National de la Recherche Agronomique, UMR866 34060, Dynamique Musculaire et Métabolisme, Montpellier , France.
  • O'Gorman DJ; Université de Strasbourg, Centre national de la recherche scientifique, Institut pluridisciplinaire Hubert Curien UMR 7178, Strasbourg , France.
J Appl Physiol (1985) ; 126(1): 88-101, 2019 01 01.
Article en En | MEDLINE | ID: mdl-30284519
Physical inactivity and sedentary behaviors are independent risk factors for numerous diseases. We examined the ability of a nutrient cocktail composed of polyphenols, omega-3 fatty acids, vitamin E, and selenium to prevent the expected metabolic alterations induced by physical inactivity and sedentary behaviors. Healthy trained men ( n = 20) (averaging ∼14,000 steps/day and engaged in sports) were randomly divided into a control group (no supplementation) and a cocktail group for a 20-day free-living intervention during which they stopped exercise and decreased their daily steps (averaging ∼3,000 steps/day). During the last 10 days, metabolic changes were further triggered by fructose overfeeding. On days 0, 10, and 20, body composition (dual energy X-ray), blood chemistry, glucose tolerance [oral glucose tolerance test (OGTT)], and substrate oxidation (indirect calorimetry) were measured. OGTT included 1% fructose labeled with (U-13C) fructose to assess liver de novo lipogenesis. Histological changes and related cellular markers were assessed from muscle biopsies collected on days 0 and 20. While the cocktail did not prevent the decrease in insulin sensitivity and its muscular correlates induced by the intervention, it fully prevented the hypertriglyceridemia, the drop in fasting HDL and total fat oxidation, and the increase in de novo lipogenesis. The cocktail further prevented the decrease in the type-IIa muscle fiber cross-sectional area and was associated with lower protein ubiquitination content. The circulating antioxidant capacity was improved by the cocktail following the OGTT. In conclusion, a cocktail of nutrient compounds from dietary origin protects against the alterations in lipid metabolism induced by physical inactivity and fructose overfeeding. NEW & NOTEWORTHY This is the first study to test the efficacy of a novel dietary nutrient cocktail on the metabolic and physiological changes occurring during 20 days of physical inactivity along with fructose overfeeding. The main findings of this study are that 1) reduction in daily steps leads to decreased insulin sensitivity and total fat oxidation, resulting in hyperlipemia and increased de novo lipogenesis and 2) a cocktail supplement prevents the alterations on lipid metabolism.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Atrofia Muscular / Suplementos Dietéticos / Metabolismo de los Lípidos / Conducta Sedentaria Tipo de estudio: Clinical_trials / Risk_factors_studies Idioma: En Revista: J Appl Physiol (1985) Año: 2019 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Atrofia Muscular / Suplementos Dietéticos / Metabolismo de los Lípidos / Conducta Sedentaria Tipo de estudio: Clinical_trials / Risk_factors_studies Idioma: En Revista: J Appl Physiol (1985) Año: 2019 Tipo del documento: Article País de afiliación: Francia