Synthesis and biological evaluation of picroside derivatives as hepatoprotective agents.
Nat Prod Res
; 33(19): 2845-2850, 2019 Oct.
Article
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| MEDLINE
| ID: mdl-30406689
ABSTRACT
Picrorhizae Rhizoma as a hepatoprotective herb, has been applied for thousands of years, and picroside was proved to be its active constituent. In this study, twelve derivatives of picroside were synthesized and the hepatoprotective activity of the derivatives was evaluated on SMMC-7721 cells. Six out of the derivatives had shown a better protective effect on H2O2-induced SMMC-7221 cells than picroside, and the activity of two derivatives (2 and 4) was stronger than that of the reference compound, silybin. Compound 2 shown the strongest protective effect (EC50 = 6.064 ± 1.295 µM).
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Bases de datos:
MEDLINE
Asunto principal:
Sustancias Protectoras
Idioma:
En
Revista:
Nat Prod Res
Año:
2019
Tipo del documento:
Article