Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination.

Park, Seong Hye; Kim, Jung Lim; Jeong, Soyeon; Kim, Bo Ram; Na, Yoo Jin; Jo, Min Jee; Yun, Hye Kyeong; Jeong, Yoon A; Kim, Dae Yeong; Kim, Bu Gyeom; You, SangGuan; Oh, Sang Cheul; Lee, Dae-Hee

Park, Seong Hye; Kim, Jung Lim; Jeong, Soyeon; Kim, Bo Ram; Na, Yoo Jin; Jo, Min Jee; Yun, Hye Kyeong; Jeong, Yoon A; Kim, Dae Yeong; Kim, Bu Gyeom; You, SangGuan; Oh, Sang Cheul; Lee, Dae-Hee.

Afiliación

Park SH; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Kim JL; Department of Oncology, Korea University Guro Hospital, Seoul, 152-703, Republic of Korea.
Jeong S; Department of Oncology, Korea University Guro Hospital, Seoul, 152-703, Republic of Korea.
Kim BR; Department of Oncology, Korea University Guro Hospital, Seoul, 152-703, Republic of Korea.
Na YJ; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Jo MJ; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Yun HK; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Jeong YA; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Kim DY; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
Kim BG; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea.
You S; Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangwon 210-702, Republic of Korea.
Oh SC; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea; Department of Oncology, Korea University Guro Hospital, Seoul, 152-703, Republic of Korea. Electronic address: sachoh@korea.ac.kr.
Lee DH; Graduate School of Medicine, Korea University College of Medicine, Seoul, 152-703, Republic of Korea; Department of Oncology, Korea University Guro Hospital, Seoul, 152-703, Republic of Korea. Electronic address: neogene@korea.ac.kr.

Biochem Biophys Res Commun ; 508(1): 1-8, 2019 01 01.

Article en En | MEDLINE | ID: mdl-30409427

Asunto(s)

Chlorophyta; Neoplasias Colorrectales/tratamiento farmacológico; Fitoterapia; Ligando Inductor de Apoptosis Relacionado con TNF/administración & dosificación; Apoptosis/efectos de los fármacos; Proteína Reguladora de Apoptosis Similar a CASP8 y FADD/antagonistas & inhibidores; Proteína Reguladora de Apoptosis Similar a CASP8 y FADD/genética; Proteína Reguladora de Apoptosis Similar a CASP8 y FADD/metabolismo; Línea Celular Tumoral; Chlorophyta/química; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/patología; Regulación hacia Abajo/efectos de los fármacos; Células HCT116; Células HT29; Humanos; Extractos Vegetales/administración & dosificación; Extractos Vegetales/toxicidad; ARN Interferente Pequeño/genética; Proteínas Represoras/antagonistas & inhibidores; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Algas Marinas/química; Ubiquitina-Proteína Ligasas/antagonistas & inhibidores; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitinación/efectos de los fármacos

Palabras clave

CHX; Codium extracts (CE); Cycloheximide; FITC; FLICE-Like inhibitory protein; FLIP; Fluorescein isothiocyanate; PARP; PBS; PI; Phosphate-buffered saline; Poly (ADP-Ribose) polymerase; Propidium iodide; SDS-PAGE; Sodium dodecyl sulfate-polyacrylamide gel electrophoresis; TNF; TNF-Related apoptosis-inducing ligand; TRAIL; Tumor necrosis factor; Ubiquitination; c-FLIP

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas Asunto principal: Neoplasias Colorrectales / Chlorophyta / Ligando Inductor de Apoptosis Relacionado con TNF / Fitoterapia Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article

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