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TAS-118 (S-1 plus leucovorin) versus S-1 in patients with gemcitabine-refractory advanced pancreatic cancer: a randomised, open-label, phase 3 study (GRAPE trial).
Ioka, Tatsuya; Ueno, Makoto; Ueno, Hideki; Park, Joon Oh; Chang, Heung-Moon; Sasahira, Naoki; Kanai, Masashi; Chung, Ik Joo; Ikeda, Masafumi; Nakamori, Shoji; Mizuno, Nobumasa; Omuro, Yasushi; Yamaguchi, Taketo; Hara, Hiroki; Sugimori, Kazuya; Furuse, Junji; Maguchi, Hiroyuki; Furukawa, Masayuki; Fukuzawa, Kengo; Kim, Jun-Suk; Yukisawa, Seigo; Takeuchi, Masahiro; Okusaka, Takuji; Boku, Narikazu; Hyodo, Ichinosuke.
Afiliación
  • Ioka T; Department of Cancer Survey and Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
  • Ueno M; Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, Japan.
  • Ueno H; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Park JO; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Chang HM; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Sasahira N; Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Kanai M; Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.
  • Chung IJ; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
  • Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
  • Nakamori S; Department of Hepatobiliary and Pancreatic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.
  • Mizuno N; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.
  • Omuro Y; Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  • Yamaguchi T; Department of Gastroenterology, Chiba Cancer Center, Chiba, Japan.
  • Hara H; Department of Gastroenterology, Saitama Cancer Center Hospital, Saitama, Japan.
  • Sugimori K; Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
  • Furuse J; Department of Medical Oncology, Kyorin University Faculty of Medicine, Tokyo, Japan.
  • Maguchi H; Center of Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.
  • Furukawa M; Department of Hepato-Biliary-Pancreatology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Fukuzawa K; Department of Surgery, Oita Red Cross Hospital, Oita, Japan.
  • Kim JS; Department of Oncology and Hematology, Korea University Guro Hospital, Seoul, South Korea.
  • Yukisawa S; Department of Medical Oncology, Tochigi Cancer Center, Utsunomiya, Japan.
  • Takeuchi M; Department of Clinical Medicine, School of Pharmacy (Biostatistics), Kitasato University, Tokyo, Japan.
  • Okusaka T; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Boku N; Division of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Hyodo I; Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: ihyodo@md.tsukuba.ac.jp.
Eur J Cancer ; 106: 78-88, 2019 01.
Article en En | MEDLINE | ID: mdl-30471651
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Oxónico / Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Leucovorina / Tegafur / Carcinoma Adenoescamoso / Resistencia a Antineoplásicos / Desoxicitidina / Antimetabolitos Antineoplásicos Tipo de estudio: Clinical_trials País/Región como asunto: Asia Idioma: En Revista: Eur J Cancer Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácido Oxónico / Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Leucovorina / Tegafur / Carcinoma Adenoescamoso / Resistencia a Antineoplásicos / Desoxicitidina / Antimetabolitos Antineoplásicos Tipo de estudio: Clinical_trials País/Región como asunto: Asia Idioma: En Revista: Eur J Cancer Año: 2019 Tipo del documento: Article País de afiliación: Japón